Evaluation of Antiinflammatory Activity of Petroleum Ether Extract from Leucaslavandulaefolia Rees in Albino Rats

Subraya, Chandrashekar K (2013) Evaluation of Antiinflammatory Activity of Petroleum Ether Extract from Leucaslavandulaefolia Rees in Albino Rats. American Journal of Phytomedicine and Clinical Therapeutics, 1 (7). pp. 562-566. ISSN 2321 – 2748

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Abstract

Background: The aim of this study was to evaluate the Invivoantiinflammatory activity of petroleum ether extract of aerial parts of Leucaslavandulaefolia Methods:The anti-inflammatory activity was evaluated by Carrageenan induced rat paw oedema to determine the activity on acute inflammation and Cotton pellet- induced granuloma to determine activity on chronic inflammation. The petroleum ether extract was administered orally at a dose of 100, 200, 400 mg/kg body weight to experimental rat. The anti-inflammatory activity was compared with standard Indomethacin. Results:Results suggested thatpetroleum ether extract of Leucaslavandulaefolia. aerial parts possess potent anti-inflammatory activity in both the models and the activity was dose dependent. In acute inflammatory model, the effect may be due to inhibition of the release of serotonin and histamine thereby preventing inflammation and also preventing the increased synthesis of prostaglandins in the surroundings of the damaged tissues.In chronic inflammatory model, the effect may be due to inhibition of cellular migration to injured site and accumulation of collagen and mucopolysaccharide. Preliminary phytochemical screening showed presence of triterpenoids and steroids in petroleum ether extract of Leucaslavandulaefolia. aerial parts. Conclusion:The result of present study confirms marked antiinflammatory activity of Leucaslavandulaefolia. The activity may attributed to steroids or triterpenoids in petroleum ether extract of L.lavandulaefolia.

Item Type: Article
Uncontrolled Keywords: Leucaslavandulaefolia; Indomethacin; Antiinflammatory
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 10 Dec 2013 11:39
Last Modified: 10 Dec 2013 11:39
URI: http://eprints.manipal.edu/id/eprint/137946

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