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Plumbagin-loaded PLGA Microspheres with Reduced Toxicity and Enhanced Antitumour Efficacy in Mice

Singh, UV and Bisht, KS and Rao, Satish BS and Devi, Uma P and Udupa, N (1996) Plumbagin-loaded PLGA Microspheres with Reduced Toxicity and Enhanced Antitumour Efficacy in Mice. Pharmaceutical Sciences, 2. pp. 407-409.

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Abstract

Plumbagin was encapsulated in microspheres using poly(D,L-lactide)-co-glycolide (PLGA) (50 : 50). The in-vitro release profile was triphasic suggesting different drug release mechanisms. The release of the drug could be controlled for about four weeks. The toxicity of plumbagin was reduced in mice after subcutaneous injection when it was encapsulated in microspheres. The volume doubling time of PLGA-loaded microspheres was significantly higher compared with the plain drug in sarcoma-I80 tumour.

Item Type: Article
Subjects: Life Sciences > MLSC Manipal
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 23 Dec 2013 10:05
Last Modified: 17 Dec 2015 09:20
URI: http://eprints.manipal.edu/id/eprint/138070

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