Study of the association of serotonin transporter triallelic 5-HTTLPR and STin2 VNTR polymorphisms with lithium prophylaxis response in bipolar disorder

Tharoor, Hema and Kotambail, Ananthapadmanabha and Sharma, Podila Satya Venkata Narasimha and Satyamoorthy, K (2013) Study of the association of serotonin transporter triallelic 5-HTTLPR and STin2 VNTR polymorphisms with lithium prophylaxis response in bipolar disorder. Psychiatric Genetics, 23 (2). pp. 77-81.

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Abstract

The 5-hydroxy tryptamine transporter (5-HTT) gene has been previously implicated in lithium response, but the roles of the triallelic 5-HTT linked promoter region (5-HTTLPR) and variable number tandem repeats in the second intron [serotonin transporter intron 2 (STin2)] have not been reported. We examined these polymorphisms in 122 patients with bipolar I disorder, among which 49 patients were classified as good responders, 49 as nonresponders, and 24 as partial responders to lithium prophylaxis. We observed significant variation in the genotype frequencies of STin2 polymorphism among the response groups (P= 0.02). There was also a significant association of haplotype consisting of the S allele of 5-HTTLPR and 10 repeat allele of STin2 with lithium response (P = 0.01) and no such relationship was found with 5-HTTLPR variants. Our data support preliminary information of a possible association of STin2 and its combined effect with 5-HTTLPR variants with lithium response and also suggest that lithium is likely to be more effective for patients carrying 5-HTT polymorphisms associated with reduced transcriptional activity.

Item Type: Article
Uncontrolled Keywords: 5-HTTLPR, bipolar disorder; lithium response; serotonin transporter; STin2 VNTR.
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Psychiatry
Depositing User: KMC Manipal
Date Deposited: 24 Dec 2013 11:15
Last Modified: 24 Dec 2013 11:15
URI: http://eprints.manipal.edu/id/eprint/138084

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