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Multimodality treatment using AK-2123, hydralazine, radiation & hyperthermia on a transplantable mouse tumour

Rao, Satish BS and Devi, Uma P (1996) Multimodality treatment using AK-2123, hydralazine, radiation & hyperthermia on a transplantable mouse tumour. Indian Journal of Medical Research, 104. pp. 182-189.

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Abstract

The in vivo response of a transplantable mouse tumour, Sarcoma 180 to AK-2123 (AK), local irradiation (RT) and local hyperthermia, as influenced by a vasoactive drug, hydralazine (HDZ), was assessed on the basis of tumour cure (complete response CR), volume doubling time (VDT), regrowth delay (RD) and animal survival up to 120 days. A single ip injection of 200 mg/kg b.wt. AK produced more than 15 per cent CR. Combination of any two agents resulted in a better response than the single agent treatments. AK in combination with 43 degrees C, 30 min (HT) was more effective than HT combination with 10 Gy. The presence of 5 mg/kg HDZ, injected immediately after 5 Gy, in combination with AK increased the therapeutic effect over that produced by AK+10Gy. Combination of all the three agents (AK+10Gy+HT) produced 100 per cent CR and prolonged disease free animal survival. A similar response could be obtained by the presence of HDZ with a lower radiation dose of 5 Gy in combination with AK and HT (AK+5Gy+HDZ+HT). This multimodality treatment offers the possibility of further reduction in the doses of individual agents, and in the possible side effects on normal tissues without compromising the tumour cure effect.

Item Type: Article
Uncontrolled Keywords: AK-2123; combination treatment; hydralazine; hyperthermia; radiation; tumour response.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 30 Dec 2013 04:07
Last Modified: 30 Dec 2013 04:07
URI: http://eprints.manipal.edu/id/eprint/138117

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