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Radiosensitizing Effect of Plumbagin on Mouse Melanoma Cells Grown in Vitro

Prasad, Satya V and Devi, Uma P and Rao, Satish BS and Kamath, Ravindra (1996) Radiosensitizing Effect of Plumbagin on Mouse Melanoma Cells Grown in Vitro. Indian Journal of Experimental Biology, 34 (9). pp. 857-858.

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Abstract

Mouse melanoma cells were treated with plumbagin, a naphthoquinone, from the plant Plumbago rosea at 0.5 microgram/ml (PI) for 60 min either alone or followed by 2 Gy gamma radiation (RT). Response to the different treatments was assessed by following the cell growth up to 5 days post treatment. PI alone produced a significant decrease in the cell count on days 3 and 4, whereas RT treatment significantly enhanced the growth inhibitory effect when compared to RT or PI alone. These findings suggests the radiosensitizing effect of PI on mouse melanoma cells in vitro, supporting the earlier in vivo findings

Item Type: Article
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 30 Dec 2013 04:27
Last Modified: 30 Dec 2013 04:27
URI: http://eprints.manipal.edu/id/eprint/138125

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