Joshi, Manjunath B and Lad, Apurva and Alevoor, Bharath Prasad S and Aswath, Balakrishnan and Ramachandra, L and Satyamoorthy, K (2013) High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation. FEBS Letters, 587 (14). pp. 2241-2246. ISSN 0014-5793
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Abstract
Neutrophils serve as an active constituent of innate immunity and are endowed with distinct ability for producing neutrophil extracellular traps (NETs) to eliminate pathogens. Earlier studies have demonstrated a dysfunction of the innate immune system in diabetic subjects leading to increased susceptibility to infections; however, the influence of hyperglycemic conditions on NETs is unknown. In the present study we demonstrate that (a) NETs are influenced by glucose homeostasis, (b) IL-6 is a potent inducer of energy dependent NET formation and (c) hyperglycemia mimics a state of constitutively active pro-inflammatory condition in neutrophils leading to reduced response to external stimuli making diabetic subjects susceptible to infections.
Item Type: | Article |
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Uncontrolled Keywords: | Neutrophil extracellular trap;Innate immunity; Diabetes; Interleukin-6; Hyperglycemia. |
Subjects: | Life Sciences > MLSC Manipal Medicine > KMC Manipal > Surgery |
Depositing User: | KMC Manipal |
Date Deposited: | 31 Dec 2013 04:06 |
Last Modified: | 31 Dec 2013 04:06 |
URI: | http://eprints.manipal.edu/id/eprint/138130 |
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