Protective Effect of Ascorbic Acid and Ginkgo Biloba Against Learning and Memory Deficits Caused by Fluoride

Jett, Raghu and Rao, Mallikarjuna C (2013) Protective Effect of Ascorbic Acid and Ginkgo Biloba Against Learning and Memory Deficits Caused by Fluoride. Toxicology and Industrial Health. pp. 1-5.

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Abstract

Fluoride is present in the ground water, World Health Organization permitted level of fluoride in the ground water is 0.5 ppm. Tooth pastes, mouth washes, tea and sea fish are the sources of fluoride. Exposure to these multiple sources results in several adverse effects in addition to the fluorosis. The present study aimed to test the effect of vitamin C and Ginkgo biloba against the behavioural deficits caused by fluoride. Rats were divided into five groups with six animals in each group (n¼ 6). Control group received ordinary tap water with 0.5 ppm of fluoride, the remaining groups received 100 ppm of fluoride for 30 days prior to fluoride exposure. Two groups of animals received 100mg/kgbodyweightofvitaminCand G. biloba for15dayspriortofluorideexposure. After 45 days, behavioural studies (T-Maze, passive avoidance) were conducted on the experimental animals. The results of the present study showed no behavioural deficits in the control group of animals however, the rats that received fluoride water exhibited impairment in their spatial learning and memory deficits. The deficits are not marked in the vitamin Cand G. biloba roups.To conclud echronic exposure to high levels of fluoride causes severe impairment in the spatial learning and memory, these deficits can be ameliorated with the vitamin C and G. biloba.

Item Type: Article
Uncontrolled Keywords: Sodium fluoride; Ginkgo biloba; Ascorbic acid; Memory disorders; Learning
Subjects: Medicine > MMMC Manipal > Anatomy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 01 Jan 2014 04:28
Last Modified: 01 Jan 2014 04:28
URI: http://eprints.manipal.edu/id/eprint/138167

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