Antioxidant and antihyperlipidemic activity of Melia azedarach Linn. extracts in rats

Kumar, Vijaya S and Sanghai, Dhirendra B and Rao, Mallikarjuna C and Shreedhara, CS (2013) Antioxidant and antihyperlipidemic activity of Melia azedarach Linn. extracts in rats. Research Journal of Pharmacy and Technology, 6 (11). pp. 1195-1199. ISSN 0974-3618

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Abstract

Melia azedarach Linn, a deciduous tree belonging to Family Meliaceae, has been used traditionally for variety of ailments. Antioxidant and antihyperlipidemic activities of the extracts of leaves of Melia azedarach were studied by in vitro antioxidant assays and in vivo effects by Triton-WR 139 induced hyperlipidaemic model and high fat diet induced hyperlipidaemia model in Wistar albino rats. The phenolic and flavonoid content was also estimated. In Triton induced hyperlipidaemic model and also in high fat induced hyperlipidaemic model, aqueous and methanolic extracts has shown significant lipid lowering activity. In antioxidant activity study, ethyl acetate extract showed better IC50 values in the DPPH and ABTS model, whereas, in o-phenanthroline assay, chloroform extract has shown better IC50 value. Phenolic content in aqueous extract was found to be more, while flavonoid content in ethyl acetate extract.

Item Type: Article
Uncontrolled Keywords: Antioxidant activity; lipid lowering activity ; Melia azedarach Linn.; phytoconstituents.
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 02 Jan 2014 04:05
Last Modified: 02 Jan 2014 04:05
URI: http://eprints.manipal.edu/id/eprint/138205

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