Timed Release of Valsartan from Programmable Release Capsules: Importance of Plasticizers

Nayak, Usha Yogendra (2013) Timed Release of Valsartan from Programmable Release Capsules: Importance of Plasticizers. Indian Journal of Pharmaceutical and Biological Research, 1 (4). pp. 102-107. ISSN 2320-9267

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The objective of the present study was to evaluate the effect of different plasticizers on the ethylcellulose coatings of capsules and its timed release characteristics. Various plasticizers such as dibutyl phthalate (DBP), triacetin (TA), glycerol, triethyl citrate (TEC), polyethylene glycol-4000 and polyethylene glycol-6000 (PEG) were studied. The physicochemical properties of the casted polymeric films such as mechanical resistance, water uptake and dryM weight loss were determined. Also the type and concentration of plasticizer on timed release of the capsule was studied. The drug release was found to be strongly dependent on the type of plasticizer and was in the order of GY>TA>PEG 6000>PEG 4000>TEC>DBP. Capsules coated with hydrophobic DBP (5%) showed good release with a lag time of 6 ± 0.5 h. DBP provided mechanically resistant coatings on the capsule and remained within the polymeric films without leaching upon exposure to the release media which helped in maintaining the lag time.

Item Type: Article
Uncontrolled Keywords: Plasticizers; Timed release; Polymeric films; Tensile strength;Dibutyl phthalate.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 02 Jan 2014 04:07
Last Modified: 02 Jan 2014 04:07
URI: http://eprints.manipal.edu/id/eprint/138206

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