Stability Indicating Analytical Method Development and Validation of Lafutidine in Tablet Dosage form by RP- HPLC

Moorkoth, Sudheer and Kumar, Sunny and Pai, Aravinda and Kamath, Venkatesh B (2013) Stability Indicating Analytical Method Development and Validation of Lafutidine in Tablet Dosage form by RP- HPLC. MintageJournal of Pharmaceutical & Medical Sciences, 2 (1). pp. 18-21.

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Abstract

Objectives:To perform stability indicating analytical method development and validation of Lafutidine in tablet dosage form by reverse phase HPLC method. Materials and Methods: The method was developed employing isocratic RP- HPLC and validated for assay of Lafutidine in tablet dosage form. The method employs the use of a UV detector. Results:The developed assay method was found to be accurate, precise, reproducible and robust and was linear over a concentration range of 20 - 100μg/mL.Conclusion: The developed method was tried for its applicability in stability indicating assay. Various stress studies were carried out and the method was able to estimate Lafutidine, but was unable to estimate the degradation products of acid and alkaline stress conditions. The method was able to quantify degradation products in oxidative stress conditions

Item Type: Article
Uncontrolled Keywords: Lafitudine; RP-HPLC; Validation; Method development
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Manipal
Date Deposited: 08 Jan 2014 04:46
Last Modified: 08 Jan 2014 04:46
URI: http://eprints.manipal.edu/id/eprint/138275

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