Bagheri, Azadeh and Chianeh, Yousef Rezaei and Rao, Pragna (2013) Role of Angiogenic Factors in Recurrent Pregnancy Loss. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2 (4). 497 -502. ISSN 2320 - 1789

PDF Review angiogenic.pdf - Published Version Restricted to Registered users only Download (275kB) | Request a copy

Abstract

Women with recurrent miscarriage (RM) often have abnormal NK cell activity. Uterine NK cells produce angiogenic factors and various interleukins. Human endometrium that expresses a variety of angiogenic growth factors and cytokines (NK-cell) may play a critical role in the abnormal endometrial angiogenesis which affect both conception and fetal development. Women with RM also have intrauterine growth restriction (IUGR) after conception. It has been shown 12-15% of women in their initial stage of pregnancies miscarry. The occurrence of miscarriage is known as having three or more continues miscarriage. This percentage is from 0.3 to 0.8% of all diagnosed pregnancies. Recurrent miscarriages have multiple aetiology. In this review article we will discuss a number of factors that may link to pregnancy complication. We focus on endometrial angiogenesis, vascular endothelial growth factor A (VEGF - A), human endothelium expresses messenger ribonucleic acids (mRNA) encoding VEGF- C, placenta growth factor (PlGF). The angiopoietins 1,2 and receptor for VEGF -A, VEGF - C, PIGF. The role of NK - cell, Interleukin - 2 (IL - 2) and IL - 15 that may lead to up - regulation of VEGF - C and Ang - 2 in secretory endometrium.

Item Type:	Article
Uncontrolled Keywords:	Recurrent miscarriage (RM); Angiogenesis; VEGF; NK cell
Subjects:	Medicine > KMC Manipal > Biochemistry
Depositing User:	KMC Manipal
Date Deposited:	08 Jan 2014 09:28
Last Modified:	08 Jan 2014 09:28
URI:	http://eprints.manipal.edu/id/eprint/138281

Actions (login required)

View Item