Bagheri, Azadeh and Chianeh, Yousef Rezaei and Rao, Pragna (2013) Role of Angiogenic Factors in Recurrent Pregnancy Loss. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2 (4). 497 -502. ISSN 2320 - 1789
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Abstract
Women with recurrent miscarriage (RM) often have abnormal NK cell activity. Uterine NK cells produce angiogenic factors and various interleukins. Human endometrium that expresses a variety of angiogenic growth factors and cytokines (NK-cell) may play a critical role in the abnormal endometrial angiogenesis which affect both conception and fetal development. Women with RM also have intrauterine growth restriction (IUGR) after conception. It has been shown 12-15% of women in their initial stage of pregnancies miscarry. The occurrence of miscarriage is known as having three or more continues miscarriage. This percentage is from 0.3 to 0.8% of all diagnosed pregnancies. Recurrent miscarriages have multiple aetiology. In this review article we will discuss a number of factors that may link to pregnancy complication. We focus on endometrial angiogenesis, vascular endothelial growth factor A (VEGF - A), human endothelium expresses messenger ribonucleic acids (mRNA) encoding VEGF- C, placenta growth factor (PlGF). The angiopoietins 1,2 and receptor for VEGF -A, VEGF - C, PIGF. The role of NK - cell, Interleukin - 2 (IL - 2) and IL - 15 that may lead to up - regulation of VEGF - C and Ang - 2 in secretory endometrium.
Item Type: | Article |
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Uncontrolled Keywords: | Recurrent miscarriage (RM); Angiogenesis; VEGF; NK cell |
Subjects: | Medicine > KMC Manipal > Biochemistry |
Depositing User: | KMC Manipal |
Date Deposited: | 08 Jan 2014 09:28 |
Last Modified: | 08 Jan 2014 09:28 |
URI: | http://eprints.manipal.edu/id/eprint/138281 |
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