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Erythroleukemia with Complex Cytogenetic Abnormalities: A case report with review of literature

*, Pooja K Suresh and Rao, Purnima S and Khadilkar, Urmila N (2013) Erythroleukemia with Complex Cytogenetic Abnormalities: A case report with review of literature. Indian Journal of Applied Research, 3 (7). pp. 538-540. ISSN 2249-555X

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Abstract

Acute Erythroleukemia (AEL) is a rare type of hematopoietic neoplasm, having a prevalence of 3-5% of all Acute Myeloid Leukemia (AML). We present a case report of acute erythroleukemia, a rare type of AML, with complex cytogenetic abnormalities. A 54-year old male presented with low grade fever and significant weight loss. Complete hemogram and a peripheral smear revealed pancytopenia with 18% blasts. It also showed features of hemolysis. Bone marrow (BM) study showed erythroid hyperplasia with erythroblasts constituting 85% of all nucleated cells and 21% myeloid blasts among non-erythroid cells. Flow cytometry revealed 23% blasts positive for CD33, CD34, CD117, CD36 and HLA-DR. Cytogenetic study revealed hypotetraploidy with numerous structural abnormalities indicating poor prognosis.

Item Type: Article
Uncontrolled Keywords: Acute Erythroleukemia, Flow cytometry, Cytogenetic abnormality
Subjects: Medicine > KMC Mangalore > Pathology
Depositing User: KMCMLR User
Date Deposited: 09 Jan 2014 11:00
Last Modified: 09 Jan 2014 11:00
URI: http://eprints.manipal.edu/id/eprint/138290

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