Effect of atorvastatin, simvastatin and lovastatin on animal models of epilepsy: a comparative study

Nayak, Veena and Adiga, Shalini and Poornima, BM and Sharma, Ravi and Garg, Arpita (2013) Effect of atorvastatin, simvastatin and lovastatin on animal models of epilepsy: a comparative study. International Journal of Current Research and Review, 4 (11). pp. 30-33.

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Abstract

Introduction: Statins are the widely prescribed drugs for hyperlipidemia. Now it is well accepted that statins not only have hypolipidemic actions but also have a number of pleotropic effects. Objective: To study the effect of atorvastatin, simvastatin and lovastatin on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures in Wistar rats. Material and methods: Atorvastatin, simvastatin and lovastatin in their therapeutically equivalent doses were administered to Wistar rats prior to induction of seizures by MES and PTZ. The abolition of hind limb extension (HLE) and duration of seizures in MES model and latency for onset of seizures as well as duration of seizures were observed in PTZ model. Statistical analysis: Data was analyzed using one way ANOVA followed by Dunnett‘s post hoc test. p≤0.05 was considered statistically significant. Results: None of the statins were able to abolish the HLE .Only simvastatin decreased the duration of seizures significantly in comparison to control group in MES model. In PTZ model simvastatin and lovastatin decreased the duration of seizures and also increased the latency for the onset of seizures in comparison to the control group. Atorvastatin increased the latency but had no effect on duration of seizures in PTZ model.

Item Type: Article
Uncontrolled Keywords: Statins; seizures; atorvastatin; simvastatin; lovastatin.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 13 Jan 2014 04:22
Last Modified: 13 Jan 2014 04:22
URI: http://eprints.manipal.edu/id/eprint/138331

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