A mitochondrial DNA variant 10398G N A in Breast Cancer among South Indians: An Original study with Meta-analysis

Rao, Lakshmi and Ramachandra, L and Satyamoorthy, K (2013) A mitochondrial DNA variant 10398G N A in Breast Cancer among South Indians: An Original study with Meta-analysis. Mitochondrion, 13. 559 -565.

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Abstract

The m.10398G N Apolymorphisminthe MT-ND3 gene has been linked to the manifestation of several neurode- generative disorders and cancers. Several research groups have analyzed the association between m.10398G N A polymorphism and Breast cancer;however,the results do not follow aconsensus.We have studied this polymor- phismin three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no as- sociation between m.10398G N A polymorphism and breast cancer [OR = 0.916 (0.743 – 1.128); P = 0.409]. Menopausal strati fication also revealed no significant association in either pre-menopausal or post- menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups,comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G N A substitution with breast cancer [OR = 1.016 (0.85 – 1.22); P = 0.86]. In conclusion, there is no evidence of association between m.10398G N A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.

Item Type: Article
Uncontrolled Keywords: Breast cancer; mtDNA; m.10398A; G Meta-analysis
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 13 Jan 2014 04:39
Last Modified: 13 Jan 2014 04:39
URI: http://eprints.manipal.edu/id/eprint/138334

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