SRD5A2 Gene Polymorphisms Affect the Risk of Breast Cancer

Rao, Lakshmi and Ramachandra, L and Satyamoorthy, K (2013) SRD5A2 Gene Polymorphisms Affect the Risk of Breast Cancer. The Breast. pp. 1-5.

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Androgens in breast cancer have been studied alone and in correlation with estrogens as estrogen to testosterone ratio. 5- a -reductase is one of the important enzymes participating in androgen metabolism, which affects androgen activity by affecting conversion of testosterone to dihydrotestosterone. We hy- pothesized that polymorphisms in the SRD5A2 gene (encoding 5- a -reductase) may affect breast cancer risk by affecting total androgen activity. Complete coding region of the SRD5A2 gene was sequenced in a group of 628 patients and 244 control samples from three southern states (Tamil Nadu, Andhra Pradesh, and Karnataka) of India. We observed three common polymorphisms in this gene; namely, A49T, V89L, and (TA) n repeats. A49T locus was monomorphic in the study population, but V89L showed a strong correlation with breast cancer ( P ¼ 0.03, OR ¼ 1.40, CI ¼ 1.02 e 1.91). (TA) 0 /(TA) 9 and (TA) 9 /(TA) 9 geno- types were at a lower risk of breast cancer ( P ¼ 0.01, OR ¼ 0.64, CI ¼ 0.46 e 0.90). We conclude that SRD5A2 genotypes significantly affect breast cancer risk in the South Indian populations.

Item Type: Article
Uncontrolled Keywords: SRD5A2 gene; Breast cancer; Polymorphism
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 13 Jan 2014 04:46
Last Modified: 13 Jan 2014 04:46

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