Nonfermenting Gram-negative Bacilli other thanM Pseudomonas aeruginosa and Acinetobacter Spp. Causing Respiratory Tractnfections in a Tertiary Care Center

Chawla, Kiran and Vishwanath, Shashidhar and Munim, Frenil C (2013) Nonfermenting Gram-negative Bacilli other thanM Pseudomonas aeruginosa and Acinetobacter Spp. Causing Respiratory Tractnfections in a Tertiary Care Center. Journal of Global Infectious Diseases, 5 (4). pp. 144-148. ISSN 0974-777X

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Abstract

Background:Nonfermenting gram-negative bacilli have emerged as important healthcare-associated pathogens. It is important to correctly identify all clinically significant nonfermenting gram-negative bacilli considering the intrinsic multidrug resistance exhibited by these bacteria.Materials and Methods: A retrospective study was undertaken to identify the various nonfermenting gram-negative bacilli other than Pseudomonas aeruginosa and Acinetobacter spp. isolated from respiratory samples ( n = 9363),to understand their clinical relevance and to analyze their antibiotic susceptibility pattern. Results:Nonfermenting gram-negative bacilli were isolated from 830 (16.4%) samples showing significant growth. Thirty-three (4%) isolates constituted nonfermenting gram-negative bacilli other than P. aeruginosa and Acinetobacter spp .Stenotrophomonas maltophilia (15, 45.5%) was the most common isolate followed by Burkholderia cepacia (4, 12.1%), Sphingomonas paucimobilis (3, 9.1%), and Achromobacter xylosoxidans (3, 9.1%). On the basis of clinicomicrobiological correlation, pathogenicity was observed in 69.7% ( n = 23) isolates. Timely and correct treatment resulted in clinical improvement in 87.9% cases.Conclusion: Any nonfermenting gram-negative bacilli isolated from respiratory tract infection should not be ignored as mere contaminant, but correlated clinically for its pathogenic potential and identified using standard methods so as to institute appropriate and timely antibiotic coverage.

Item Type: Article
Uncontrolled Keywords: Intrinsic resistance; Nonfermenting gram-negative bacilli; S. maltophilia
Subjects: Medicine > KMC Manipal > Microbiology
Depositing User: KMC Manipal
Date Deposited: 14 Jan 2014 09:16
Last Modified: 14 Jan 2014 09:16
URI: http://eprints.manipal.edu/id/eprint/138348

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