Model based simulation for Type I diabetic patients

Kamath, Surekha (2013) Model based simulation for Type I diabetic patients. Asian-American Journal of Chemistry, 1 (1). pp. 11-19.


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Insulin injection therapy is widely practical for the maintenance of Blood Glucose levels within the normoglycemic range (70-100mg/dL) for type I diabetics. A robust PID controller was designed to deliver insulin via a mechanical pump in type I diabetic patients. For the design of PID controller a linear diabetic patient model is necessary. Hence the nonlinear diabetic patient model was linearized. Uncertainty in the nonlinear model was characterized by up to ±40% variation in eight physiological parameters. A sensitivity analysis identified the 3 parameter set having the most significant effect on glucose and insulin over the frequency range of interest. Controller performance can be assessed in terms its ability to track a normoglycemic set point(81.1 mg/dL) in response to a 50g meal disturbance.

Item Type: Article
Uncontrolled Keywords: Insulin modeling, diabetic regulation, mathematical modeling
Subjects: Engineering > MIT Manipal > Instrumentation and Control
Depositing User: MIT Library
Date Deposited: 16 Jan 2014 06:53
Last Modified: 16 Jan 2014 06:53

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