Khanna, Vinay and Khanna, Ruchee and Hebbar, Shrikiran and Shashidhar, V and Mundkur, Suneel C and Munim, Frenil and Annamalai, Karthick and Nayak, Deepak and Mukhopadhayay, Chiranjay (2011) Primary moebic meningoencephalitis in an infant due to naegleria fowleri. Case Reports in Neurological Medicine, 2011. pp. 1-3.

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Abstract

Primary amoebic meningoencephalitis (PAM) caused by free-living amebae Naegleria fowleri is a rare and fatal condition. A fatal case of primary amoebic meningoencephalitis was diagnosed in a 5-month-old infant who presented with the history of decrease breast feeding, fever, vomiting, and abnormal body movements. Trophozoites of Naegleria fowleri were detected in the direct microscopic examination of CSF and infant was put on amphotericin B and ceftazidime. Patient condition deteriorated, and he was discharged against medical advice and subsequently expired. We also reviewed previously reported 8 Indian cases of primary amoebic meningoencephalitis (PAM) and observed that for the last 5 years, none of the patients responded to amphotericin B. Has an era of amphotericin B-resistant Naegleria fowleri been emerged? Management strategy of PAM needs to be reviewed further.

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