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Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis

*, Divya Premchandran and Madhyastha, Sampath and Saralaya, Vasudha and *, Teresa Joy and *, Sudhanshu Sekhar Sahu and *, Rachana K (2013) Effect of Prenatal Isotretinoin on Postnatal Development of Cornea and Lens in Albino Wistar Rat: A Morphometric and Histopathlogical Analysis. IOSR Journal 0f Pharmacy, 3 (11). pp. 35-40. ISSN 2319-4219

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Abstract

Isotretinoin is a known teratogen affecting the neuronal differentiation in developing brain. Apart from its effects on brain and other craniofacial malformations, it is also known to cause failure of detachment of the lens from the surface ectoderm. Interestingly very little is known about the teratogenic effect of isotretinoin on the development of eye. Hence in the present study we evaluated the morphometric and histopathological changes in developing cornea and lens in rats during postnatal development.The pregnant rats received16mg/kg dose of isotretinoin during gestation day 1to 7 or 12 to 18. The control group received equivalent volume of vegetable oil instead of isotretinoin. The pups were sacrificed on day 7 or 14 or 30 for histopathological and morphometric analysis using haematoxylin and eosin staining.The results of the study clearly demonstrate that prenatal isotretinoin severely affects the development and growth of the cornea in both treatment regimes. There was also a considerable damage to the morphology of the lens.This preliminary animal study clearly demonstrates the teratogenic effect of isotretinoin on developing cornea and lens.

Item Type: Article
Uncontrolled Keywords: Developing rat cornea, Developing rat lens, Prenatalisotretinoin, Rat eye development
Subjects: Medicine > KMC Mangalore > Anatomy
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 17 Jan 2014 11:22
Last Modified: 17 Jan 2014 11:22
URI: http://eprints.manipal.edu/id/eprint/138439

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