Rai, Rajalakshmi and Prabhu, Latha V. and Ranade, Anu V and Kini, Hema and Rao, Chitra P and Shetty, Suchetha K (2013) Quantification of retinal thickness with biochemical parameters in sildenafil induced male rats. International Journal of Recent Scientific Research, 4 (12). pp. 2048-2051. ISSN 0976-3031

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Abstract

The present study was designed to evaluate the sildenafil induced retinal changes in male rats, relate it with alterations in nitric acid and phosphodiesterase level in the eyeball.Adult male albino rats of Wistar strain were divided into control group and experimental groups containing six rats in each group. Experimental animals were injected with the solution of sildenafil citrate dissolved in distilled water for the duration of the experiment. Retinal changes were observed in histological sections with light microscopy and level of nitric oxide and phosphodiesterase in eyeball was calculated and analyzed. Retinal thickness increased significantly in one month group animals. In three months group at 8mg/kbw did not show any significant differences whereas at 10mg/kbw thickness significantly decreased (p<0.01) when compared to that of control group. Histological examination revealed changes in the thickness of retina significantly in the form of retinal edema. The results observed in the present study were dose dependent and dependent on the duration of the exposure of sildenafil. There was an increase in the retinal thickness in one month group in this study which was coinciding with increased level of nitric oxide.

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