A comparative study between Yakshagana artists and healthy controls for antioxidant markers and liver function parameters

Ramanan, Harini and Thomas, Ann T and Kasturi, Amrita Rishi Harisha and Srinivasan, Mukund P and Jaiprakash, Chethan A and Syed, Safiulla B and Somashekar, Puneeth H and Mungli, Prakash and Nayak, Veena (2012) A comparative study between Yakshagana artists and healthy controls for antioxidant markers and liver function parameters. International Journal of Health Sciences and Research, 2 (1). pp. 50-56. ISSN 2249-9571

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Abstract

Objectives: The lifestyle of yakshagana artists is comparatively different from other people which predispose them to physical and mental stress. In the current study yakshagana artists are analysed for antioxidant markers and liver function parameters to assess the extent of stress and liver damage as compared to healthy controls. Methods: Serum samples from yakshagana artists (n=78) and healthy controls (n=80) were analysed for liver function parameters and antioxidant markers. Liver function parameters were determined by automated analyzer. Markers of antioxidant status were estimated spectrophotometrically. Results: There was significant increase in serum AST, serum ALT, serum total bilirubin, serum GST and serum MDA, and significant decrease in serum total thiols in yakshagana artists when compared to healthy controls (p<0.0001). On Pearson’s correlation serum AST, serum ALT correlated positively with serum GST (p<0.0001) and negatively with serum total thiols (p<0.0001). Serum MDA correlated negatively with serum total thiols (p<0.0001). Conclusion: Results of our study indicates there is presence of stress in yakshagana artists which may be because of their lifestyle and consumption of alcohol in them may compound this stress and can cause impairment in liver function.

Item Type: Article
Uncontrolled Keywords: Yakshagana artists; total thiols; GST, MDA; antioxidant status.
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 27 Jan 2014 04:23
Last Modified: 27 Jan 2014 04:23
URI: http://eprints.manipal.edu/id/eprint/138527

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