Nayak, Veena and Adiga, S and Poornima, BM and Sharma, R and Garg, A and Shetty, M and Kamath, S and Hegde, M and Koshy, SS (2013) Effect of chronic administration of atorvastatin, simvastatin and lovastatin on animal models of epilepsy. International Journal of Current Research, 5 (19). pp. 61-65.

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Abstract

Introduction: Statins, the widely used hypolipidemics drugs have a number of pleotropic effects. Objective: To study the effect of chronic administration of atorvastatin, simvastatin and lovastatin on maximal electroshock and pentylenetetrazole induced seizures in Wistar rats. Material and Methods: After obtaining institutional animal ethics committee clearance the study was conducted in male wistar rats. The animals were dosed with the various statins for 30 days. The effect of statins on maximal electroshock and pentylenetetrazole induced seizures was then studied. The animals were then sacrificed and the brain tissue was used for antioxidant estimation. Results: Statins showed a protective effect against seizures in both the models. The levels of glutathione were increased and malonadialdehyde decreased in the brain tissue in statin treated groups. The present study confirms the anticonvulsant action of statins, their antioxidant action being the possible mechanism.

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