Spontaneous tumour lysis syndrome in a case of multiple myeloma - A rare occurrence

Saravu, Kavitha and Kumar, Suresh S and Shastry, Ananthakrishna Barkur and Kurien, Annamma and Prabhu, Ravindra and Kumar, Rishikesh (2013) Spontaneous tumour lysis syndrome in a case of multiple myeloma - A rare occurrence. Australasian Medical Journal, 6 (3). pp. 168-171. ISSN 1836-1935

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We describe a case of a 40-year-old male patient who was found to have multiple myeloma with spontaneous tumour lysis syndrome (TLS), following a compression fracture of the L-2 vertebrae. Multiple myeloma was confirmed by bone marrow analysis and the M-band on serum protein electrophoresis. Hyperuricaemia (26.2 mg/dL), hyperkalaemia (> 7.0 mEq/L), hyperphosphatemia (16.2 mg of phosphorus/dL), normocalcemia and acute kidney injury, prior to anticancer treatment suggested spontaneous TLS. Inciting events for tumour lysis, such as chemotherapy, dehydration and exposure to steroids were absent. Patient received hydration, hypourecemic drugs and haemodialysis. This case report highlights the rare presentation of multiple myeloma with spontaneous TLS.

Item Type: Article
Uncontrolled Keywords: Hyperphosphatemia; hyperkalaemia; hyperuricaemia; normocalcaemia; renal failure.
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Nephrology
Depositing User: KMC Manipal
Date Deposited: 30 Jan 2014 10:19
Last Modified: 30 Jan 2014 10:19
URI: http://eprints.manipal.edu/id/eprint/138580

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