Chronic Myeloid Leukemia with Hyperdiploidy: A Case Report with Review of Literature

Belurkar, Sushma V and Manohar, Chethan and Kurien, Annamma (2013) Chronic Myeloid Leukemia with Hyperdiploidy: A Case Report with Review of Literature. Indian Journal of Medical Sciences, 67 (7). pp. 188-192. ISSN 0019-5359

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Abstract

Chronic myeloid leukemia (CML) is a common marrow stem cell neoplasm characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Studies have shown that CML can be associated with various other cytogenetic abnormalities. 5-10% of these cases can show complex translocations involving other chromosomes in addition to Ph chromosome. Here, we report a Ph- positive CML patient with a hyperdiploid karyotype who presented clinically in chronic phase but progressed to blast crisis in spite of treatment with Imatinib. This case highlights the significance of cytogenetic abnormalities on the prognosis in CML

Item Type: Article
Uncontrolled Keywords: Chronic myeloid leukemia; Hyperdiploidy; Philadelphia chromosome
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 31 Jan 2014 04:09
Last Modified: 16 Sep 2015 12:37
URI: http://eprints.manipal.edu/id/eprint/138607

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