Remedial Effects of Novel 2,3-disubstituted Thiazolidin-4-ones in Chemical Mediated Inflammation

Mudgal, Jayesh and Gowdra, Vasantharaju S and Mathew, Geetha and Nayak, Pawan G and Reddy, Nitin D and Namdeo, Neelesh and Kumar, Ravilla R and Kantamaneni, Chaitanya and Rao, Mallikarjuna C and Kutty, Gopalan N (2014) Remedial Effects of Novel 2,3-disubstituted Thiazolidin-4-ones in Chemical Mediated Inflammation. Chemico-Biological Interactions, 210. pp. 34-42.

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Abstract

Three thiazolidin-4-one derivatives were synthesized, purified and characterized by chromatographic and spectroscopic methods. In the in vitro assays, these compounds inhibited reactive oxygen species (ROS), nitrite and cytokine generation in RAW 264.7 murine macrophages and whole blood. These deriv- atives attenuated carrageenan-induced acute inflammation in rats. The most effective compound 4C pos-sessed identical anti-inflammatory action at two doses (50 and 100 mg/kg). Further, the effect of compound 4C on locally induced inflammatory mediators was investigated in carrageenan-induced air pouch inflammation in rats. In this model, compound 4C inhibited the cytokines, tumor necrosis factor (TNF)-a and interleukin (IL)-6 (systemic and local). Additionally, compound 4C was able to reduce locally elevated prostaglandin-E 2 (PGE 2). Inhibition of leukocyte infiltration by compound 4C was correlated with reduced locally released myeloperoxidase (MPO). To conclude, compound 4C corrected the inflam- matory condition by negative effect on cytokine (TNF-a, IL-6) network and prostaglandin-E 2 generation

Item Type: Article
Uncontrolled Keywords: Thiazolidin-4-one; Cytokines; Cyclo-oxygenase; Prostaglandins; Myeloperoxidase; Inflammation
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 31 Jan 2014 04:14
Last Modified: 31 Jan 2014 04:14
URI: http://eprints.manipal.edu/id/eprint/138608

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