Secreted frizzled related proteins: Implications in cancers.

Surana, Rohit and Sikka, Sakshi and Cai, Wanpei and Shin, Eun Myoung and Warrier, S and Tan, Hong Jie Gabriel and Arfuso, Frank and Fox, Simon A and Dharmarajan, Arun M and Kumar, Alan Prem (2014) Secreted frizzled related proteins: Implications in cancers. Biochimica et Biophysica Acta., 1845 (1). pp. 53-65. ISSN 0006-3002.

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Abstract

TheWnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis,and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzledrelated proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly toWnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRPmembers is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP familymembers and their role in different cancers. This reviewcomprehensively covers all the available information on the role of SFRPmolecules in various human cancers.

Item Type: Article
Additional Information: Copy right of this article is belongs to Elsevier Science.
Uncontrolled Keywords: Wnt signalling,Secreted frizzled-related proteins, Cancer and cancer stem cells,Drug targets.
Subjects: Regenerative Medicine > MIRM Bangalore
Depositing User: MCON Library
Date Deposited: 01 Feb 2014 05:43
Last Modified: 29 Apr 2014 06:22
URI: http://eprints.manipal.edu/id/eprint/138618

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