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Synthesis of methoxy-substituted chalcones and in vitro evaluation of their anticancer potential

Aranjani, Jesil Mathew (2013) Synthesis of methoxy-substituted chalcones and in vitro evaluation of their anticancer potential. Chemical biology & drug design, 82. pp. 732-742.

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Abstract

Methoxy-substituted chalcones, 3 were obtained using simple, efficient method from 2-naphtylethanone, 1 and aromatic aldehydes, 2. The in vitro cytotoxicity activities of the chalcones against a panel of three human cancer cell lines were explored. The tested compounds were found to possess significant cytotoxic activity. The DNA strand break and damage was quantified through alkaline comet assay, flow cytometric analysis, and chromatin condensation studies, which revealed the apoptotic nature of the compounds. Compound 3c, (3-(3,4,5-trimethoxyphenyl)-1-(2-naphthyl) prop-2-en-1- one) showed highest cytotoxicity of 0.019 lM against HeLa, 0.020 lM against HCT15 and 0.022 lM against = A549. Compound 3e, (3-(3,5-dimethoxyphenyl)-1-(2- naphthyl) prop-2-en-1-one) showed better IC50 values against all the three cell lines employed for the study.

Item Type: Article
Uncontrolled Keywords: Apoptosis; chalcones; chromatin condensation; cytotoxicity; DA damage; flow cytometry.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Depositing User: KMC Manipal
Date Deposited: 03 Feb 2014 04:15
Last Modified: 03 Feb 2014 04:15
URI: http://eprints.manipal.edu/id/eprint/138628

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