Bhat, Ramesh Y and Kurien, Annamma and Kakkar, Shruti and Padma, MS and Raju, Vamsi Sivarama and George, Sherin (2013) Spontaneous recovery of haemophagocytic syndrome in an adolescent girl receiving anti-tuberculosis treatment. Journal of Microbiology and Infectious Diseases, 3 (4). pp. 211-213.

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Abstract

Infection associated haemophagocytic syndrome (HPS) is rare and could be potentially fatal. Reactive HPS has been reported with various infections including tuberculosis. Tuberculosis associated HPS is more common in adults than in children. Severe pancytopenia due to HPS complicating tuberculosis and while on therapy has been rarely described. Success of therapy depends on early initiation of treatment. We describe herein a 13-years old girl who developed severe pancytopenia while on anti-tuberculous treatment. Her bone marrow aspirate showed trilineage dyspoiesis, histiocytes with phagocytosed debris and haemophagocytosis confirming a reactive haemophagocytic syndrome. She recovered completely with supportive treatment.

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