The antioxidant status in human population based on the concept of prakruthi in Ayurveda

Mallya, Madhukar H and Shenoy, Revathi P and Ramakrishnan, Sreejith and Thampi, Linta and Stevens, Rashmi and Kamath, Sethukumar M and Nayak, Anupama V and Rao, Anjali (2008) The antioxidant status in human population based on the concept of prakruthi in Ayurveda. Asian Pacific Journal of Tropical Medicine, 1 (4). pp. 40-43.

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Objective: In the Ayurvedic system of medicine, body constitution (prakruthi) is said to play a vital role in the disease process as well as in its progression. Free radical toxicity is also involved in the etiopathogenesis of many disorders. Hence, in the present study an attempt has been made to correlate the body constitution type and the antioxidant status of that prakruthi, Methods: Healthy volunteers from Manipal University Campus, South Karnataka, India were classified into three main human constitutions (prakruthi) and their possible combinations and their serum total antioxidant activity was determined. Results: There was a significant negative correlation of the total antioxidant status with the pitta prakruthi whereas vata and kapha constitutions showed no significant correlation with the total antioxidant status. Conclusion: Ayurveda classifies each individual based on his/her prakruthi into three categories of Doshas: Vata, Pitta and Kapha (collectively known as Tridoshas). The three Doshas are fundamental regulatory principles responsible for maintaining organism functioning and manifesting those characteristics typifying each individual, that is, in equilibrium Tridoshas signify health and an imbalance leads to disease. Thus, in this study a significantly decreased antioxidant status in the Pitta group would render them more susceptible to damage by oxidative stress. Hence, we suggest that supplementation with antioxidants of herbal (Ayurvedic) origin to such a group would prove to be beneficial - opening up the arena for pharmacogenomics and customized antioxidant drug administration based on the prakruthi of an individual.

Item Type: Article
Uncontrolled Keywords: Ayurveda; Antioxidant status; Prukruthi; Vata; Pitta; Kapha.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 10 Feb 2014 04:53
Last Modified: 10 Feb 2014 06:21

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