Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats

Kondamudi, Phani Krishna and Kovelamudi, Hemalatha and Mathew, Geetha and Nayak, Pawan G and Rao, Mallikarjuna C and Shenoy, Rekha R (2014) Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats. The ScientificWorld Journal, 2014.

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Abstract

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods: The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results: The levels of MPO, TBARS, and tissue nitrite increased significantly (

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 11 Feb 2014 10:40
Last Modified: 11 Feb 2014 10:40
URI: http://eprints.manipal.edu/id/eprint/138760

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