Imunoreactive α2-macroglobulin in Tubal Pregnancy: A Possible Tool for Early Diagnosis

Roche, Maya and Kamath, Saritha U (2013) Imunoreactive α2-macroglobulin in Tubal Pregnancy: A Possible Tool for Early Diagnosis. International Journal of the A.J. Institute of Medical Sciences, 2 (1). pp. 13-16.

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Abstract

About 2% of all pregnancies are ectopic, where the implantation of the developing blastocyst occurs outside the uterus. More than 98% of ectopic pregnancies occur in the fallopian tubes. Haemorrhage from ectopic pregnancy is still the leading cause of maternal death in the first trimester, presenting a diagnostic challenge to the clinician. Besides signs and symptoms, the clinician depends only on 2 tools - the ultrasound and the quantitative estimation of β-hCG (human chorionic gonadotropin) for diagnosing the condition. In cases where both these do not give a clear picture as to the location of the implantation, precious time is lost waiting for a repeat β-hCG reading which might still prove to be inconclusive. Currently, there is no single serum marker available to detect tubal pregnancy. This study found a significant rise in immunoreactive serum α2-macroglobulin determined by radial immunodiffusion in ectopic pregnancy (p<0.001) when compared to normal nonpregnant and normal pregnant women, and discusses the relevance of this finding in the clinical setting.

Item Type: Article
Uncontrolled Keywords: α2-macroglobulin; Ectopic pregnancy; Immunoreactivity; Tubal pregnancy
Subjects: Allied Health > MCOAHS Manipal > Medical Laboratory Tech
Medicine > MMMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 11 Feb 2014 10:47
Last Modified: 13 Feb 2014 10:48
URI: http://eprints.manipal.edu/id/eprint/138768

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