Chronopharmacokinetics

Sudhakar, GK and Pai, Aravinda and Bhasker, Vijaya and Jeyaprakash, RS and Pai, Vasudev (2013) Chronopharmacokinetics. Archives of Pharmacy and Biological Sciences, 1 (3). pp. 102-105.

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Abstract

Conventional drug delivery systems have been based on homeostatic theory (that is, biological physiology is constant over time).But existence of circadian rhythm for almost all body functions like heart rate, blood pressure ,body temperature, hormonal levels, gastric secretions, renal functions have been supported by chronobiological studies. This lead to origin of a new concept (Chronopharmacokinetics).Chronopharmacokinetics correlates temporal changes in drug absorption, distribution, metabolism and excretion with the moment of administration of drug. It is established that drugs show higher bioavailability when administered in the morning than when taken in the evening. Since physiological functions and pathological status are due to circadian rhythm, during dosing regimen can be synchronised with biological rhythms for increasing therapeutic efficacy and reducing the incidence of adverse effects.

Item Type: Article
Uncontrolled Keywords: Circadian rhythm ; Plasma concentration; Chronopharmacokinetic studies.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 25 Feb 2014 04:33
Last Modified: 25 Feb 2014 04:33
URI: http://eprints.manipal.edu/id/eprint/138936

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