Resveratrol for Prenatal-Stress-Induced oxidative damage in growing brain and its consequences on survival of neurons

Madhyastha, Sampath and *, Sudhanshu Sekhar Sahu and Rao, Gayathri (2014) Resveratrol for Prenatal-Stress-Induced oxidative damage in growing brain and its consequences on survival of neurons. J Basic ClinPhysiolPharmacol, 25 (1). pp. 63-72.

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Abstract

Background: Prenatal-stress-induced neuronal damagein offspring is multifactorial, including oxidative damagein the developing brain. Resveratrol is known to exert itsneuroprotective potentials by upregulating several antioxidant systems. Hence, the study was undertaken toevaluate the neuroprotective effect of resveratrol againstprenatal-stress-induced hippocampal damage and oxidative damage in neonate rat brains. Methods: Pregnant rats were subjected to restraint stressduring early or late gestational period. Another set of ratsreceived resveratrol during the entire gestational periodalong with early or late gestational stress. The study parameters included several antioxidant studies directlyfrom rat brain homogenate on the 40th postnatal day andhippocampal neuronal assay on the 21st postnatal day. Results: Early as well as late gestational stress resulted ina significant increase in lipid peroxidation and advancedoxidation protein products and decrease in total antioxidantactivity and nitric oxide levels in rat brain homogenate.The neurons of the dentate gyrus were severely affectedin early and late gestational stress, and only the neurons ofthe CA3 region were adversely affected in late gestational stress. Administration of resveratrol reversed the prenatalstress-induced oxidative damage and neurons of dentategyrus but not the CA3 hippocampal neurons. Conclusions: These results show the neuroprotective abilitiesof resveratrol against prenatal-stress-induced oxidativedamage in neonatal rat brain.

Item Type: Article
Uncontrolled Keywords: dentate gyrus; hippocampal neurons; oxidative stress; prenatal stress; resveratrol.
Subjects: Medicine > KMC Mangalore > Anatomy
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 26 Feb 2014 06:29
Last Modified: 26 Feb 2014 06:29
URI: http://eprints.manipal.edu/id/eprint/138951

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