Effect of Vanillin on lipid profile in a model of hyperlipidemia, a preliminary study

Belagali, Yogesh and Ullal, Sheetal D and Shoeb, Ahsan and Bhagwat, Vani and *, Ramya K and Maskeri, Rakshitha (2013) Effect of Vanillin on lipid profile in a model of hyperlipidemia, a preliminary study. Indian journal of experimental biology, 51 (4). pp. 288-291. ISSN 0019-5189

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To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group. Reduction in total cholesterol was significant at 200 and 400 mg/kg doses compared to hyperlipidemic control. The results demonstrate that vanillin at a dose of 200 and 400 mg/kg body weight lowers the serum triglyceride, VLDL-C and total cholesterol level significantly in high fat diet induced hyperlipidemic rats. However there was no significant effect on the lipid profile at 100 mg/kg dose. There were no statistically significant changes in the HDL-C and LDL-C levels at any of the given doses.

Item Type: Article
Uncontrolled Keywords: hyperlipidemia, Lipid Profile, Vanillin
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 26 Feb 2014 06:29
Last Modified: 26 Feb 2014 06:29
URI: http://eprints.manipal.edu/id/eprint/138952

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