Jetti, Raghu and Rao, Mallikarjuna C and Somayaji, Nagabhooshana S and Babu, Prakash Billakanti (2013) The Ameliorative Effect of Ascorbic acid and Ginkgo biloba on Learning and Memory Deficits Associated with Fluoride Exposure. Interdisciplinary Toxicology, 6 (4). pp. 217-221. ISSN 1337-6853
![]() |
PDF
Raghu jetti.pdf - Published Version Restricted to Registered users only Download (155kB) | Request a copy |
Abstract
Chronic exposure to fluoride causes dental and skeletal fluorosis.Fluoride exposure is also detrimental to soft tissues and organs. The present study aimed at evaluation of the effect of Ginkgo biloba and ascorbic acid on learning and memory deficits caused by fluoride exposure. Male Wistar rats were divided into five groups (n=6).Group 1 control. Groups 2 to 5 received 100 ppm of sodium fluoride over 30 days. Groups 3, 4 and 5 were further treated for 15 days receiving respectively 1% gum acacia solution, 100 mg/kg body weight ascorbic acid, and 100mg/kg body weight Ginkgo biloba extract. After 45 days, all animals were subjected to behavioural tests. The results showed that fluoride affected learning and memory. Fluoride causes oxidative stress and neurodegeneration, thereby affecting learning and memory. Ascorbic acid and Ginkgo biloba were found to augment the reversal of learning and memory deficits caused by fluoride ingestion.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Fluoride; Ascorbic acid; Ginkgo biloba; Learning and memory deficits |
Subjects: | Medicine > KMC Manipal > Anatomy Medicine > MMMC Manipal > Anatomy Pharmacy > MCOPS Manipal > Pharmacology |
Depositing User: | KMC Manipal |
Date Deposited: | 06 Mar 2014 09:25 |
Last Modified: | 26 Dec 2015 10:35 |
URI: | http://eprints.manipal.edu/id/eprint/139030 |
Actions (login required)
![]() |
View Item |