The Ameliorative Effect of Ascorbic acid and Ginkgo biloba on Learning and Memory Deficits Associated with Fluoride Exposure

Jetti, Raghu and Rao, Mallikarjuna C and Somayaji, Nagabhooshana S and Babu, Prakash Billakanti (2013) The Ameliorative Effect of Ascorbic acid and Ginkgo biloba on Learning and Memory Deficits Associated with Fluoride Exposure. Interdisciplinary Toxicology, 6 (4). pp. 217-221. ISSN 1337-6853

[img] PDF
Raghu jetti.pdf - Published Version
Restricted to Registered users only

Download (155kB) | Request a copy

Abstract

Chronic exposure to fluoride causes dental and skeletal fluorosis.Fluoride exposure is also detrimental to soft tissues and organs. The present study aimed at evaluation of the effect of Ginkgo biloba and ascorbic acid on learning and memory deficits caused by fluoride exposure. Male Wistar rats were divided into five groups (n=6).Group 1 control. Groups 2 to 5 received 100 ppm of sodium fluoride over 30 days. Groups 3, 4 and 5 were further treated for 15 days receiving respectively 1% gum acacia solution, 100 mg/kg body weight ascorbic acid, and 100mg/kg body weight Ginkgo biloba extract. After 45 days, all animals were subjected to behavioural tests. The results showed that fluoride affected learning and memory. Fluoride causes oxidative stress and neurodegeneration, thereby affecting learning and memory. Ascorbic acid and Ginkgo biloba were found to augment the reversal of learning and memory deficits caused by fluoride ingestion.

Item Type: Article
Uncontrolled Keywords: Fluoride; Ascorbic acid; Ginkgo biloba; Learning and memory deficits
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > MMMC Manipal > Anatomy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 06 Mar 2014 09:25
Last Modified: 26 Dec 2015 10:35
URI: http://eprints.manipal.edu/id/eprint/139030

Actions (login required)

View Item View Item