Significance of Maternal and Cord Blood Nucleated Red Blood Cell Count in Pregnancies Complicated by Preeclampsia

Hebbar, Shripad and Misha, Mehak and Rai, Lavanya (2014) Significance of Maternal and Cord Blood Nucleated Red Blood Cell Count in Pregnancies Complicated by Preeclampsia. Journal of Pregnancy, 2014. pp. 1-4.

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Abstract

Objectives. To evaluate the effect of preeclampsia on the cord blood and maternal NRBC count and to correlate NRBC count and neonatal outcome in preeclampsia and control groups. Study Design.This is a prospective case control observational study.Patients and Methods.Maternal and cord blood NRBC counts were studied in 50 preeclamptic women and 50 healthy pregnant women.Using automated cell counter total leucocytecount was obtained and peripheralsmearwas prepared to obtain NRBC count.Corrected WBC count and NRBC count/100 leucocytes in maternal venous blood and in cord blood were compared between the 2groups.Results.No significant differences were found in corrected WBC count in maternal and cord blood in cases and controls.Significant differences were found in mean cord blood NRBC count in preeclampsia and control groups (40.0±85.1 and 5.9±6.3 ,푃=0.006 ). The mean maternal NRBC count in two groups was 2.4±9.0 and 0.8±1.5 ,respectively( 푃=0.214). Cord blood NRBC count cut off value ≤ 13 could rule out adverse neonatal outcome with a sensitivity of 63% and specificity of 89%. Conclusion. Cord blood NRBC are significantly raised in preeclampsia. Neonates with elevated cord blood NRBC counts are more likely to have IUGR, low birth weight, neonatal ICU admission, respiratory distr ess syndrome, and assisted ventilation. Below the count of 13/100 leucocytes, adverse neonatal outcome is quite less likely.

Item Type: Article
Subjects: Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 08 Mar 2014 10:01
Last Modified: 08 Mar 2014 10:01
URI: http://eprints.manipal.edu/id/eprint/139060

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