A critical analysis of the concept of secondary Oral Hhypoglycemic Agent (OHA) failure in type 2 diabetes at a tertiary care hospital

Vidyasagar, Sudha and Nataraj, * and Varma, Muralidhar and Prashanth, CK and Rao, Yeshwanth and Kavitha, B (2011) A critical analysis of the concept of secondary Oral Hhypoglycemic Agent (OHA) failure in type 2 diabetes at a tertiary care hospital. International Journal of Diabetes in Developing Countries, 31 (3). pp. 161-165.

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Abstract

Data from UKPDS study suggests that the onset of ß cell dysfunction in diabetes occurs well before the development of hyperglycemia. To study the concept of secondary OHA failure in type 2 diabetes patients of more than 10 years duration in a tertiary care hospital. A retrospective analysis of all the cases of type 2 diabetes mellitus of more than 10 years duration from 2002 to 2003 was done and the data was divided into three groups: oral hypoglycemic agents (OHA) only, Insulin only, OHA + insulin. ANOVA/Students t test was the primary statistical test used. Odds ratio and 95% CI were calculated to compare risks of other diseases and drug use. 62.35% were on only OHAs, 8.82% on only insulin and 28.82% on both insulin and OHAs. This confirms good efficacy of OHAs. Diabetic population in our study tends to have a preserved beta cell function and secondary OHA failure is a late feature.

Item Type: Article
Uncontrolled Keywords: OHA failure; Beta cell dysfunction; Type 2 diabetes.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Medicine
Depositing User: KMC Manipal
Date Deposited: 19 Mar 2014 06:20
Last Modified: 19 Mar 2014 06:20
URI: http://eprints.manipal.edu/id/eprint/139149

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