Comparison of photo-optical and mechanical methods for prothrombin time test

Nayak, Deepak M and Manohar, Chethan and Saroja, * and Patil, Asha (2013) Comparison of photo-optical and mechanical methods for prothrombin time test. Indian Journal of Applied Research, 3 (9). pp. 457-458. ISSN 2249 - 555X

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Abstract

Background: The PT measures the activity of the so-called extrinsic and common pathways of coagulation. Automated coagulation analyzers have replaced the manual methods to meet the increasing test load in many laboratories. Two distinct automated or semi-automated methods exist based on optical and mechanical clot detection. Aim: To compare the reliability of prothrombin time test using mechanical and photo-optical methods in a semi-automated coagulation analyzer. Materials and methods: Prothrombin time data was collected retrospectively conducted on 100 samples run on mechanical & optical modes on Amax Destiny Plus™ analyzer (Trinity Biotech) in the month of November 2012. The standard deviation (SD), Coefficient of Variance (C.V.) & R² value were calculated. Results: The instrument results showed good precision and coefficient of variation. Statistical analysis demonstrated an excellent correlation between the photo-optical and mechanical methods for PT (R² 0.995). Conclusion: The results for the prothrombin time test obtained by the photo-optical detection method is reliable and is statistically equivalent as those obtained by the mechanical detection method.

Item Type: Article
Uncontrolled Keywords: prothrombin time; mechanical method, photo-optical method, automation, coagulation.
Subjects: Allied Health > MCOAHS Manipal > Medical Laboratory Tech
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 20 Mar 2014 09:55
Last Modified: 20 Mar 2014 09:55
URI: http://eprints.manipal.edu/id/eprint/139169

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