Nayak, Deepak M and Shastry, Indira K and Patil, Asha and Prabhu, Ravindra (2013) Overestimation of hemoglobin due to paraproteins in myeloma: A case report. Journal of Chemical, Biological and Physical Sciences, 4 (1). pp. 375-378. ISSN 2249 –1929

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Abstract

Paraproteins have been shown to interfere with a number of clinical laboratory tests due to their precipitating quality. We describe herein a patient diagnosed with multiple myeloma, for which the automated cyanmethemoglobin method displayed a falsely elevated hemoglobin level. The calculated hematocrit agreed with a spun hematocrit, suggesting that the hemoglobin concentration was being overestimated by the automated counter. The plasma turbidity and the increased IgM levels, confirmed the presence of paraproteins which caused the discrepancy. This case aims to highlight some of the lesser known, rare causes of preanalytical errors concerning hemoglobin estimation by autoanalyzers.

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