Aleukemic variant of mast cell leukemia- A rare phenomenon

Singh, Brij Mohan Kumar and Manohar, Chethan and Nayak, Deepak M and Belurkar, Sushma V (2013) Aleukemic variant of mast cell leukemia- A rare phenomenon. International Journal of Scientific and Research Publications, 3 (5). pp. 1-4. ISSN 2250-3153

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Mast cell leukemia is a rare variant of mastocytosis, accounting for less than 1% of all mast cell disease and pose one of the greater challenges in the management of these patients, with a grave prognosis. Diagnosis of this neoplasm rests on the detection of abnormal mast cells in marrow and subsequent spill over to the peripheral blood. We report a case of aleukemic variant of mast cell leukemia in a pediatric patient, presenting with fever and chest pain for 10 days. The peripheral smear showed a picture of pancytopenia with abnormal/ atypical lymphoid cells. Bone marrow aspirate showed dense aggregates of atypical, hypogranular and partially degranulated mast cells expressing toluidine blue and CD117 positivity.

Item Type: Article
Uncontrolled Keywords: Mast cell; mastocytosis; aleukemic variant of Mast cell leukemia.
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 22 Mar 2014 09:21
Last Modified: 05 Nov 2016 15:09

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