Hemophagocytic lymphohistiocytosis masquerading as sepsis

Nayak, Deepak M and Manohar, Chethan and Nalini, B (2013) Hemophagocytic lymphohistiocytosis masquerading as sepsis. International Journal of Clinical and Surgical Advances , 1 (1). pp. 2-5. ISSN 2321-9351

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Abstract

Hemophagocytic Lymphohistiocytosis (HLH) or Hemophagocytic syndrome is a potentially lethal disorder due to an uncontrolled immune response to a triggering agent. It can be primary or secondary to neoplastic, infectious or autoimmune processes. It is characterized by theproliferation of histiocytes with phagocytosis of formed elements of blood.A ten-year-old boy, developed a progressive multiorgan failure due to septicemia. The bone marrow study was performed which showed atypical lymphoid cells and moderate hemophagocytosis. Prolonged fever, hepatosplenomegaly, hypofibrinogenemia, hyperferritinemia and hypertriglyceridemia confirmed HLH diagnosis. The childreceived intensive care support therapy but eventually succumbed to sepsis. Hence, anearly diagnosis of HLH is quintessential for a better outcome.

Item Type: Article
Uncontrolled Keywords: Hemophagocytic lymphohistiocytosis; atypical lymphoid cells; septicemia.
Subjects: Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Paediatrics
Depositing User: KMC Manipal
Date Deposited: 22 Mar 2014 10:17
Last Modified: 22 Mar 2014 10:17
URI: http://eprints.manipal.edu/id/eprint/139191

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