A Retrospective Evaluation of Mean Platelet Volume as a Discriminating Factor in Thrombocytopenia of Hypoproductive and Hyperdestructive Aetiologies

Khanna, Ruchee and Nayak, Deepak M and Manohar, Chetan and Dhar, Murali (2013) A Retrospective Evaluation of Mean Platelet Volume as a Discriminating Factor in Thrombocytopenia of Hypoproductive and Hyperdestructive Aetiologies. Journal of Evolution of Medical and Dental Sciences, 2 (47). 9059 -9065.

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Abstract

BACKGROUND: Bone marrow examination is the gold standard test in determining the cause of thrombocytopenia; whether it is of hypoproductive or hyperdestructive nature. However,this process has distinct disadvantages such as being invasive, not feasible in critical situations and is often not preferred by clinicians and patients alike. The introduction of platelet indices in automated hematology analyzers has provided a small window into the cause of thrombocytopenias in the recent years. Mean platelet volume (MPV) has evoked much interest in this regard. This study aimed at assessing the predictive value of MPV in determining the aetiology of thrombocytopenia.MATERIALS AND METHODS: We analyzed 100 case s of thrombocytopenia (platelet count < 100x10 3 / cu.mm) on a retrospective basis for a period of one month. The cases were divided into 2 groups: with and without bone marrow diseases; based on individual pathophysiology. A statistical analysis was done to assess predictive values, odds ratio and confidence intervals and also to elicit a cut - off value for MPV. RESULTS : The mean MPV in the group with marrow disease was 8.95fl while the group without marrow disease was 9.42fl. The difference in MPV between the 2 groups was not statistically significant (P value: 0.088). The sensitivity and specificity scores as tabulated by the receptor operating characteristic (ROC) curve at a cut - off of 9.35fl were 69% and 55% respectively.CONCLUSIONS:The study concluded that although MPV may provide a small initial insight into the aetiology of thrombocytopenia, it is limited by insufficient sensitivity and specificity. A bone marrow examination continues to be the gold standard to differentiate the hypoproductive and hyp erdestructive thrombocytopenias

Item Type: Article
Uncontrolled Keywords: Mean platelet volume; Thrombocytopenia; Bone marrow disease
Subjects: Departments at MU > Statistics
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 27 Mar 2014 04:32
Last Modified: 27 Mar 2014 04:32
URI: http://eprints.manipal.edu/id/eprint/139232

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