Plasma protein thiols, ceruloplasmin, C-reactive protein and RBC acetylcholinesterase in patients undergoing intrauterine insemination

Prabhu, Krishnananda and Kumar, Pratap and Adiga, Satish Kumar and Rao, Anjali and Lanka, Anupama and Singh, Jaipal (2008) Plasma protein thiols, ceruloplasmin, C-reactive protein and RBC acetylcholinesterase in patients undergoing intrauterine insemination. In: International Conference on"Free Radicals and Natural Products in Health” , 14-16 Feb 2008, Rajasthan, Jaipur, India. (Submitted)

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Abstract

Introduction: Animal and human studies have shown that insemination resulted in increase in polymorphonuclear leucocytes in uterine cavity and uterine motility by reflex activation of cholinergic system. Studies also suggested that oxidative stress could affect assisted reproduction. Hypothesis: Changes in levels of acetylcholinesterase, protein thiols, ceruloplasmin and C- reactive proteins following intrauterine insemination may be responsible for overall poor success rate of intrauterine insemination. Materials and methods: 42 patients aged 31 ± 4.65 years (Mean ± S.D) with primary infertility selected for intrauterine insemination. All of them had induced ovulation with clomiphene citrate 50mg from day 2- day 6.After taking the consent, 2 ml of blood was withdrawn before and after 24 hours of intrauterine insemination for biochemical estimations Results: We observed a significant decrease in plasma ceruloplasmin, protein thiols and RBC acetylcholinesterase (p<0.001) following intrauterine insemination compared to respective pre procedure levels. High sensitive C- reactive protein (HS- CRP) showed a marginal increase after intrauterine insemination. Conclusion: Fluctuations in levels of the above parameters points to their role in female reproductive system and their possible role in predicting the outcome of the intrauterine insemination.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Obstetrics & Gynaecology
Depositing User: KMC Manipal
Date Deposited: 31 Mar 2014 04:27
Last Modified: 31 Mar 2014 04:27
URI: http://eprints.manipal.edu/id/eprint/139235

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