Malik, Rimshida and Pai, Priya and Prabhu, Krishnananda and Bhaskaranand, Nalini and Rao, Anjali (2009) Effect of reno protective therapy on plasma thiols and ferric reducing /antioxidant power in children with nephrotic syndrome. In: 36th annual conference of association of clinical biochemists of India, 5-7 Nov 2009, Kochi. (Submitted)

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Abstract

Introduction: Oxidative damage by free radicals has been implicated in number of clinical disorders including renal injury. In the present study, biomarkers of oxidative stress like protein thiols and ferric reducing/antioxidant power were estimated in children with nephrotic syndrome before onset of reno protective therapy and after 4 yrs of treatment. Aim: to evaluate the effectiveness of reno protective therapy on the levels of these parameters. Materials and methods: Plasma protein thiols and ferric reducing/antioxidant power were measured in Children suffering from nephrotic syndrome attending Kasturba Medical College Hospital, Manipal before the onset of reno protective therapy and after a period of four years of reno protective therapy and their respective levels were compared. Results: We observed a significant decrease in plasma protein thiols and ferric reducing/antioxidant power (p < 0.001) after treatment as compared to their initial values. Conclusion: This decrease may indicate that antioxidant status of these children was decreased as there was a decreased demand for them due improvement in clinical state.

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