Effect of reno protective therapy on plasma thiols and ferric reducing /antioxidant power in children with nephrotic syndrome

Malik, Rimshida and Pai, Priya and Prabhu, Krishnananda and Bhaskaranand, Nalini and Rao, Anjali (2009) Effect of reno protective therapy on plasma thiols and ferric reducing /antioxidant power in children with nephrotic syndrome. In: 36th annual conference of association of clinical biochemists of India, 5-7 Nov 2009, Kochi. (Submitted)

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Abstract

Introduction: Oxidative damage by free radicals has been implicated in number of clinical disorders including renal injury. In the present study, biomarkers of oxidative stress like protein thiols and ferric reducing/antioxidant power were estimated in children with nephrotic syndrome before onset of reno protective therapy and after 4 yrs of treatment. Aim: to evaluate the effectiveness of reno protective therapy on the levels of these parameters. Materials and methods: Plasma protein thiols and ferric reducing/antioxidant power were measured in Children suffering from nephrotic syndrome attending Kasturba Medical College Hospital, Manipal before the onset of reno protective therapy and after a period of four years of reno protective therapy and their respective levels were compared. Results: We observed a significant decrease in plasma protein thiols and ferric reducing/antioxidant power (p < 0.001) after treatment as compared to their initial values. Conclusion: This decrease may indicate that antioxidant status of these children was decreased as there was a decreased demand for them due improvement in clinical state.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 31 Mar 2014 04:36
Last Modified: 31 Mar 2014 04:36
URI: http://eprints.manipal.edu/id/eprint/139252

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