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Evaluation of Salivary Magnesium and Thiols in Attention Deficit Hyperactivity Disorders

Archana, E and Prabhu, Bhavya K and Pai, Priya and Shenoy, Revathi P and Prabhu, Krishnananda and Rao, Anjali Evaluation of Salivary Magnesium and Thiols in Attention Deficit Hyperactivity Disorders. In: 36th annual conference of association of clinical biochemists of India, 5-7 Nov 2009, Kochi. (Submitted)

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Abstract

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most frequently diagnosed childhood psychiatric disorders. Based on various empirical estimates, symptoms of ADHD persist into adulthood in about 30-50% of the childhood cases. Studies have shown RBC and plasma cholinesterase show unique patterns of differences in patients with various neuropsychiatric disorders including ADHD as compared to controls indicating involvement of cholinergic system in these disorders. Antagonism of neuronal nicotinic acetylcholine receptors have shown to ameliorate the core symptoms of various neurological disorders associated with hyper kinesis, attention and memory loss. Patients lacking circulating serum ceruloplasmin presented with neurodegeneration. Animal experiments showed lack of ceruloplasmin was associated redox injury in the brains. Also copper deficiency has been implicated in neurological impairment seen in Wilson disease. Aim: To estimate salivary ceruloplasmin and cholinesterase in subjects coming with ADHD and to compare their respective values in age and sex matched controls Materials and methods: After obtaining clearance from institutional ethics committee, we estimated salivary ceruoplasmin and cholinesterase from 12 controls 9 subjects in the age group 5 – 12 yrs and their values were compared. Results: Pseudocholinesterase showed significant increase (p< 0.001) in subjects as compared to controls. Ceruloplasmin levels showed marginal decrease in subjects as compared to controls however it was not statistically significant. Conclusion: Results further substantiate the role for cholinergic system and ceruloplasmin in ADHD. Also our results show that saliva can be an effective alternative non-invasive tool for evaluation of such disorders.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 31 Mar 2014 04:19
Last Modified: 31 Mar 2014 04:19
URI: http://eprints.manipal.edu/id/eprint/139253

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