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Evaluation of salivary magnesium and thiols in attention deficit hyperactivity disorders

Archana, E and Prabhu, Bhavya K and Pai, Priya and Shenoy, Revathi P and Prabhu, Krishnananda and Rao, Anjali Evaluation of salivary magnesium and thiols in attention deficit hyperactivity disorders. In: 36th annual conference of association of clinical biochemists of India, 5-7 Nov 2009, Kochi. (Submitted)

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Abstract

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent behavioral disorder in children and the pathophysiology remains obscure. Ionic magnesium Mg2+ depletion has long been known to cause hyperexcitability with convulsive seizures in rodents, effects that have been reversed by treatment with magnesium. A positive influence of magnesium in the prevention and treatment of hyperactivity in children is more and more frequently raised in the literature as magnesium level was found to be moderately decreased in plasma and erythrocytes and the Mg2+ -ATPase activity was reduced in ADHD children. Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. Regarding MDA levels studies have shown conflicting reports some showing increase and others showing decreased levels. Aim: To estimate Megnesium and protein thiols in saliva of children with ADHD and to compare their respective levels in controls. Materials and methods: Salivary Megnesium and protein thiols were estimated in children with ADHD (n = 9) and heir respective levels were compared with controls (n = 12). Results: Salivary thiols showed a significant increase in subjects (p < 0.001) as compared to controls and magnesium showed significant decrease in subjects (p < 0.01) as compared to controls. Conclusion: This result substantiates the role of oxidative stress and magnesium in pathophysiology of neurological disorders. Also our results show that saliva can be an effective alternative non-invasive tool for evaluation of such disorders.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 31 Mar 2014 04:24
Last Modified: 31 Mar 2014 04:24
URI: http://eprints.manipal.edu/id/eprint/139254

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