Comparison Of plasma phosphdiesterase activity in premenstrual and menstrual period

Rajyalakshmi, M and Warrier, Indu R and Prabhu, Krishnananda and Rao, Anjali (2009) Comparison Of plasma phosphdiesterase activity in premenstrual and menstrual period. In: 36th annual conference of association of clinical biochemists of India, 5-7 Nov 2009, Kochi. (Submitted)

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Abstract

Introduction: Both menstruation and pregnancy are inflammatory conditions that cause a degree of physiological ischemia-reperfusion. Contractility of uterine smooth muscle is essential for the cyclic shedding of the endometrial lining and also for expulsion of the fetus during parturition. Cyclic nucleotide phosphodiesterases (PDEs) are a diverse enzyme group with multiple regulatory properties and wide tissue distribution. Such activity includes cyclic adenosine (cAMP) and guanosine monophosphate (cGMP) breakdown. Cyclic nucleotide accumulation has been implicated in dilatation of intact tonic spiral arteries uterus and in relaxation of myometrium. Isoforms of the PDE4 family are shown to be involved in smooth muscle contraction and inflammation. PDE4 inhibitors have been shown to prevent inflammation-induced preterm delivery. Materials and methods: Plasma phosphodiesterase were estimated in healthy female participant students of Kasturba Medical College, Manipal with mean age 21 yrs in the premenstrual period and on first day of menstruation. Their respective premenstrual and menstrual levels were compared. Results: We observed that there is a significant increase (p <0.05) in the phosphodiesterase levels in the menstrual period as compared to their respective values in the premenstrual period. Conclusion: Our results show that there is a significant change in levels of plasma phosphodiesterase indicating their possible role in uterine contraction.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 31 Mar 2014 06:53
Last Modified: 31 Mar 2014 06:53
URI: http://eprints.manipal.edu/id/eprint/139260

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