Antioxidant activity in intrauterine growth restriction

Prabhu, Krishnananda and Sharma, Stuti and Mohan, Sheethal and Rao, Anjali (2008) Antioxidant activity in intrauterine growth restriction. In: Ambicon 2008 16th Annual National Conference of Medical Biochemists of India, 13-16 Nov 2008 , Chandigarh, India. (Submitted)

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Abstract

Introduction: Intrauterine growth restriction (IUGR) is a term used to describe a condition in which the fetus is smaller than expected for the number of weeks of pregnancy. This may occur when the fetus does not receive the necessary nutrients and oxygen needed for growth and development of organs and tissues because of uteroplacental insufficiency and fetoplacental hypoxemia. It has been suggested that oxidative stress may cause endothelial dysfunction and that endothelial dysfunction may lead to reduced release of vasodilating agents such as nitric oxide (NO). Oxidant status of the cell modulates angiogenesis, which is critical for follicular growth, corpus luteum formation endometrial differentiation and embryonic growth. Aim: The purpose of this study is to evaluate the role of maternal oxidative stress in lowering neonatal birth weight. Materials and methods: Plasma protein thiols and malondealdehyde were measured in ultrasonography proven IUGR cases in third trimester (28 – 34 weeks) attending Kasturba Medical College Hospital, Manipal and their levels were compared with respective levels of normal pregnant women of same gestational period. Results: We observed both protein thiols and malondealdehyde were increased in IUGR patients as compared to their respective levels in normal pregnant woman. Conclusion: In women with IUGR the processes of lipid peroxidation increased.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 31 Mar 2014 06:54
Last Modified: 31 Mar 2014 06:54
URI: http://eprints.manipal.edu/id/eprint/139261

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