Assessment of Frequency of Micronucleated Exfoliated Buccal cells in Relation to Oxidative Stress in Oral Lichen Planus in Coastal Karnataka,India

Mukherjee, Madhurima and Gyawali, Prabin and Thakur, Rajesh Kumar and Shenoy, Revathi P and Rao, Anjali (2011) Assessment of Frequency of Micronucleated Exfoliated Buccal cells in Relation to Oxidative Stress in Oral Lichen Planus in Coastal Karnataka,India. Asian Pacific Journal of Tropical Disease, 1 (4). 287-288.

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Abstract

Objective:To assess the frequency of micronucleus in exfoliated buccal mucosa cells of patients with oral lichen planus (OLP) in relation to free radical toxicity since OLP is considered to be a precancerous lesion. Methods:The micronucleus frequency in exfoliated buccal mucosa cells of patients with OLP was assessed and compared to those in healthy subjects.Results:A significant increase (P<0.004) in frequency of micronucleated exfoliated cells (MEC) was observed in patients with OLP when compared to normal subjects.Conclusions:It can be concluded that DNA damage in MEC of OLP patients may be a consequence of increased free radical toxicity.

Item Type: Article
Uncontrolled Keywords: Buccal cells; Micronucleus; Oral lichen planus
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 02 Apr 2014 09:01
Last Modified: 02 Apr 2014 09:01
URI: http://eprints.manipal.edu/id/eprint/139273

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