Serum butyrylcholinesterase levels in oral cancer

Prabhu, Krishnananda and Naik, Divya and Ray, Satadru and Vadiraj, * and Rao, Anjali and Kamath, Asha (2011) Serum butyrylcholinesterase levels in oral cancer. In: ACEM 2011, International Conference, 4–6 July 2011, Bangkok, Thiland. (Submitted)

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Introduction: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies recognized nowadays, and represents a public health problem. Its early detection is the better alternative to provide a good quality of life for the patients. Identification of molecular markers (or biomarkers) which can predict disease progression is necessary for better management of these disorders A correlation of cholinesterase with tumorigenesis, cell proliferation and cell differentiation has been observed. Studies have shown that levels of butyrylcholinesterase (pseudocholinesterase) can be used as a biochemical marker in the management of cervical cancer. Aim: To estimate and compare serum butyrylcholinesterase levels in healthy controls and biopsy proven oral cancer patients before definitive therapy. Materials and methods: Institutional Ethics Committee gave us the permission conduct this study. After obtaining consent from biopsy proven oral cancer patients (n= 39) (before onset of any definitive treatment) and age and sex matched healthy controls (n = 20), 2ml of blood was collected in plain vacutainers. After clot formation samples were centrifuged and serum was collected for estimation of butylrylcholinesterae. Results and discussion: Pretreatment serum BChE levels were significantly elevated (p < 0.0001) in oral cancer patients as compared to that of controls and also there was a significant increase in BChE levels (p = 0.005) with advancing stage in oral cancer patients. This may implicate a role for serum BChE in pathophysiology of oral cancer prognosis.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 03 Apr 2014 04:51
Last Modified: 03 Apr 2014 04:51

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